Intervertebral disc degeneration (IDD) is a common disorder, and traditional treatment approaches have focused on symptom relief. However, advances in regenerative medicine and tissue engineering have generated increased interest in biological therapies and approaches that promote disc regeneration. Stem cell therapy, total disc replacement, and scaffolds generated through tissue engineering hold promise in the treatment of IDD. Stem cell transplantation can stimulate tissue regeneration through the use of different types of stem cells. Additionally, the use of nanofiber scaffolds derived from natural materials can support intervertebral disc regeneration. Other strategies, such as growth factors, gene therapy, and platelet-rich plasma, also demonstrate potential. Among the mechanical regenerative approaches, dynamic stabilization is an important method that can increase disc height and hydration. However, further research and comprehensive clinical trials are needed. Regenerative treatments targeting intervertebral disc tissue present promising alternative options to traditional methods, but more studies are required to determine their safety and longterm effectiveness.