Obesity, the prevalence of which is increasing day by day in the industrializing Western society, is one of the important public health issues in our country and brings a burden to the health economy. As well as it plays a role in the development of cardiovascular, metabolic, orthopedic, psychiatric and neurosurgical diseases, and also intervertebral disc degeneration. When the effect of obesity on the development of disc degeneration is examined, it is thought that in addition to excessive mechanical load, chronic low-grade inflammation may also be effective through biochemical mechanisms whose details are not fully elucidated. In this review, it was aimed to evaluate and summarize the role of obesity in the pathogenesis and development of intervertebral disc degeneration in the light of the existing literature.