Melatonin has been investigated effectively in many human trials to combat cell senescence, oxidative stress, inflammation, and cellular apoptosis and to restore tissue function. However, uncertainties remain regarding the effects of melatonin on the intervertebral disc. This study; its old molecule`s, for which positive reports have been reported from many scientists, including its effectiveness and reliability, was compiled with the aim of focusing on the epiphenomena of its more fundamental, yet undefined actions on intervertebral disc degeneration.